In this guide, we told you how to unlock the stages in the Binding of Isaac game.
Binding of Isaac Unlock Guide
Updated January 4, 2023.
Binding of Isaac Unlock Boss
- A Radioactive Spider: Defeat Boss in Basement 2.
- Spelunker: Defeat Boss in Caves 2.
- The Womb: Defeat Boss in The Depths 2.
- The Harbingers: Defeat Boss in The Depths 2.
- A Cube of Meat Collectible: Defeat Boss in The Depths 2.
- A Halo Collectible: Defeat Boss in The Depths 2 or The Womb 2 (use the Bible)
- Monstro’s Tooth: Defeat all the bosses in the Basement.
- Lil Chubby: Defeat all the bosses in the Caves.
- Loki’s Horns: Defeat all the bosses in The Depths.
- The Book of Revelations: Defeat any Harbinger and or Horseman.
- Little Steven: Defeat Steven.
- Little C.H.A.D: Defeat C.H.A.D or the Headless Horseman.
- Little Gish: Defeat Gish.
- A Lump Of Coal: Defeat Krampus.
Binding of Isaac Unlock Ending
- Judas: Defeat boss in The Womb 2 1st time
- The Book Of Belial: Defeat boss in The Womb 2 for the 1st time
- The Noose: Defeat boss in The Womb 2 2nd time
- The Nail: Defeat boss in The Womb 2 3rd time
- A Quarter: Defeat boss in The Womb 2 4th time
- A Fetus In A Jar: Defeat boss in The Womb 2 5th time
- Everything’s Terrible!: Defeat boss in The Womb 2 6th time
- The Wafer: Defeat boss in The Womb 2 7th time
- Money = Power: Defeat boss in The Womb 2 8th time
- It Lives: Defeat boss in The Womb 2 9th time
- ???: Defeat boss in The Womb 2 for the tenth time.
- The Poop: Defeat boss in The Womb 2 10th time
- The Relic: Defeat boss in The Womb 2 using Magdalene.
- Sack Of Pennies: Defeat boss in The Womb 2 using Cain.
- Robo-Baby: Defeat boss in The Womb 2 using Judas.
- D6: Defeat boss in The Womb 2 using ???.
- Razor Blade: Defeat boss in The Womb 2 using Eve.
- Mom’s Knife: Defeat boss in Sheol using Isaac.
- Guardian Angel: Defeat boss in Sheol using Magdalene.
- Bomb Bag: Defeat boss in Sheol using Cain.
- Monster Manuel: Defeat boss in Sheol using Judas.
- Forget Me Now: Defeat boss in Sheol using ???.
- Demon Baby: Defeat boss in Sheol using Eve.
Binding of Isaac Unlock Tasks
- Magdalene: Have 7 heart containers in a single playthrough
- Yum Heart: Have 7 heart containers in a single playthrough
- Cain: Have 55 Coins at once
- Lucky Foot: Have 55 Coins at once
- Eve: 2 or more deals with the devil in one playthrough.
- Dead Bird: 2 or more deals with the devil in one playthrough.
- Super Bandage: Defeat four Harbingers and or Horsemen in a single playthrough.
- Small Rock: Destroy 50 Rocks (multiple playthroughs)
- The Bean: Destroy 50 Poops piles (multiple playthroughs)
- Mr. Mega: Destroy 10 Tinted Rocks rocks (multiple playthroughs)
- Mom’s Bottle Of Pills: Use 20 Blood Donation Machines (multiple playthroughs)
- The Book Of Sin: Defeat all of the Seven Deadly Sins (multiple playthroughs)
- The Gamekid: Visit 10 Arcades (multiple playthroughs)
- The Necronomicon: Use the XIII Death Tarot Card 4 times (multiple playthroughs)
- The Parasite: Collect 2 of these items in a single play: Bob’s Rotten Head, Brother Bobby, Dead Cat, Max’s Head, Tammy’s Head or also Dead Bird.
- Shears: Die 100 times.
- The Common Cold: Collect 2 of either Roid Rage, The Virus, and Growth Hormones in a single playthrough.
- Mom’s Contacts: Collect Mom’s Eye and Mom’s Heels/Mom’s Lipstick/Mom’s Pad/Mom’s Bra
- Something from the Future (Steven): Defeat bosses in The Basement 42 times.
- Something Cute (C.H.A.D.): Finish The Caves 20 times.
- Something Sticky (Gish): Finish The Depths 30 times.
- Basement Boy: Clear the Basement without taking damage.
- Spelunker Boy: Clear the Cave without taking damage.
- Dark Boy: Clear The Depths without taking damage.
- Mamas Boy: Clear the Womb without taking damage.
- Golden God: Collect 131/132 original items (not Wrath of the Lamb)
Binding of Isaac Unlock Wrath of the Lamb
- Samson: Complete Depths 2 without taking 2 Treasure Room items
- D20: Complete the Cathedral using Isaac.
- Celtic Cross: Complete the Cathedral using Maggy
- Abel: Complete the Cathedral using Cain.
- Curved Horn: Complete the Cathedral using Judas.
- Sacrificial Dagger: Complete the Cathedral using Eve.
- Rainbow Baby: Complete the Cathedral using ???.
- Bloody Lust: Complete Womb 2 using Samson.
- Blood Rights: Complete Sheol using Samson.
- Bloody Penny: Complete the Cathedral using Samson.
- The Polaroid: Complete the Cathedral 6 times.
- Isaac’s Head: Complete the Chest using Isaac.
- Maggy’s Faith: Complete the Chest using Maggy.
- Cain’s Eye: Complete the Chest using Cain
- Judas’ Tongue: Complete the Chest using Judas
- Eve’s Bird Foot: Complete the Chest using ???
- ???’s Soul: Complete the Chest using Eve
- Samson’s Lock: Complete the Chest using Samson
Challenge Rewards Unlockables in Wrath of the Lamb
- The Candle: Complete 1st Challenge
- Lucky Toe: Complete 2nd Challenge
- Burnt Penny: Complete 3rd Challenge
- Guppy’s Tail: Complete 4th Challenge
- Fish Head: Complete 5th Challenge
- Epic Fetus: Complete 6th Challenge
- Super Fan: Complete 7th Challenge
- Spider Butt: Complete 8th Challenge
- Counterfeit Penny: Complete 9th Challenge
- Daddy’s Love: Complete 10th Challenge
Tasks Unlockables in Wrath of the Lamb
- Guppy’s Hairball: Transform Isaac into a Cat.
- Dad’s Key: Defeat ???.
- A Forgotten Horseman: Destroy 30 Tinted Rocks
- Something Icky!: Finish The Womb 16 times.
- The Left Hand: Defeat Ultra Pride.
- Platinum God: Collect 197/198 items in the game and also unlock all the secrets.
Binding of Isaac Unlock Characters
- Judas: Defeat boss in The Womb 2 1st time
- ???: Defeat boss in The Womb 2 for the tenth time.
- Magdalene: Have 7 heart containers in a single playthrough
- Cain: Have 55 Coins at once
- Eve: 2 or more deals with the devil in one playthrough.
- Samson: Complete Depths 2 without taking 2 Treasure Room items
- Azazel: make three deals with the devil in one run
- Lazarus: once the player has four or more soul hearts (or black hearts) at once during a run
- Eden: defeat Mom’s Heart for the first time
- The Lost: Videoguide below
- Lilith: (DLC Afterbirth) defeat Greed Mode with Azazel
- Keeper: (DLC Afterbirth) donate 1000 coins to the Greed machine
- Apollyon: (DLC Afterbirth+) defeat Mega Satan for the first time
- The Forgotten: (DLC Afterbirth+) Videoguide below
