No Good Deed
Start this mission by meeting with Alphonse Renaud in Rhodes. The traveling doctor tells you that someone has stolen his medical wagon.
Unlocked: Complete Chapter 3’s “American Distillation” and two additional RDR2 story quests. This mission can only be done between 6am and 6pm. Head to the northeast of Rhodes saloon to find this stranger. After the cutscene, ride to the highlighted area on the map in the northeast.
The wagon is by the river southwest of Macomb’s End. Kill the thugs that come in the way, then drive the wagon back. You will be attacked by a few riders during your journey back as well, so be ready for that as well.